Publications
Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry
Cancer trends in young adults, often under 50 years, reflect recent changes in carcinogenic exposures, which could foreshadow the future overall disease burden. Previous studies reported an increase in early onset colorectal cancer, which could partly reflect the...
One in five young British adults has signs of the silent killer dubbed ‘human foie gras’ that causes fat to build-up around the liver and can prove deadly
A study of more than 4,000 young adults found more than 20 percent are walking around with dangerous levels of fat in their liver. This gives them twice the risk of suffering a cardiac event such as a heart attack, and in extreme cases can lead to liver cancer or the...
Gilead shores up hope for NASH cocktail with a glimpse at positive proof-of-concept data
On display today at the International Liver Congress are topline results from a proof-of-concept study testing cilofexor (nonsteroidal farnesoid X receptor or FXR agonist) and firsocostat (acetyl-CoA carboxylase or ACC inhibitor). Out of 20 patients who were treated...
High rates of liver disease progression and mortality observed in patients with NAFLD/NASH
Two independent national studies have reported high rates of liver disease progression and mortality among patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH). The studies reported today at The International Liver Congress™ 2019...
Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030
Non-alcoholic fatty liver disease and nonalcoholic steatohepatitis can lead to advanced liver disease. Both conditions are becoming increasingly prevalent as the epidemics of obesity and diabetes continue to increase. A mathematical model was built to understand how...
NLRP3 Deletion Inhibits the Non-alcoholic Steatohepatitis Development
Abstract The cleavage and secretion of pro-inflammatory cytokines IL-1β and IL-18 is regulated by NLRP3 (NACHT, LRR, and PYD domain-containing protein 3) inflammasome activation. Kupffer cells (KCs) are implicated in the pathogenesis of various liver...
Simultaneous MR quantification of hepatic fat content
Abstract Non-alcoholic steatohepatitis (NASH) is characterized at histology by steatosis, hepatocyte ballooning and inflammatory infiltrates, with or without fibrosis. Although diamagnetic material in fibrosis and inflammation can be detected with quantitative...
New treatments in non-alcoholic fatty liver disease
Abstract BACKGROUND Non-alcoholic fatty liver disease is the fastest growing cause of liver disease in the Western world, yet there is no approved pharmacotherapy. While lifestyle modifications remain the mainstay of treatment, only a proportion of individuals are...
Protein profiling and functional analysis of liver mitochondria
Abstract Mitochondrial dysfunction is closely associated with the pathogenesis of nonalcoholic steatohepatitis (NASH). The aim of the present study was to comprehensively determine mitochondrial abnormalities in NASH by detecting the proteomics in liver mitochondria...
Liver Biopsy in Type 2 Diabetes: Implications for NASH
Abstract Recent studies report a prevalence of non-alcoholic fatty liver disease (NAFLD) of between 70% and 80% in patients with metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM). Nevertheless, it is not possible to differentiate between simple steatosis and...
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