by ltsiwpadmin | Jul 5, 2017 | Overview & Epidemiology, Publications
Abstract Non-alcoholic steatohepatitis (NASH) is characterized at histology by steatosis, hepatocyte ballooning and inflammatory infiltrates, with or without fibrosis. Although diamagnetic material in fibrosis and inflammation can be detected with quantitative...
by ltsiwpadmin | Jul 4, 2017 | Diagnostics & Therapeutic Advancements, Publications
Abstract BACKGROUND Non-alcoholic fatty liver disease is the fastest growing cause of liver disease in the Western world, yet there is no approved pharmacotherapy. While lifestyle modifications remain the mainstay of treatment, only a proportion of individuals are...
by ltsiwpadmin | Jun 30, 2017 | Overview & Epidemiology, Publications
Abstract Mitochondrial dysfunction is closely associated with the pathogenesis of nonalcoholic steatohepatitis (NASH). The aim of the present study was to comprehensively determine mitochondrial abnormalities in NASH by detecting the proteomics in liver mitochondria...
by ltsiwpadmin | Jun 1, 2017 | Policy & Public Affairs, Publications
Abstract Recent studies report a prevalence of non-alcoholic fatty liver disease (NAFLD) of between 70% and 80% in patients with metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM). Nevertheless, it is not possible to differentiate between simple steatosis and...
by ltsiwpadmin | Jun 1, 2017 | Policy & Public Affairs, Publications
Abstract CONTEXT Patients with nonalcoholic fatty liver disease have a high cardiovascular risk, but statins are rarely prescribed because of fear of hepatotoxicity. OBJECTIVE To prospectively assess the long-term safety of statins in patients with prediabetes/type 2...
by ltsiwpadmin | May 26, 2017 | Policy & Public Affairs, Publications
Abstract BACKGROUND & AIMS Lean nonalcoholic fatty liver disease (NAFLD) is defined as NAFLD that develops in patients with a body mass index (BMI) less than 25 kg/m2. We investigated the differences between lean NAFLD and NAFLD in overweight and obese persons,...
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