by bryan | Apr 15, 2019 | Diagnostics & Therapeutic Advancements
On display today at the International Liver Congress are topline results from a proof-of-concept study testing cilofexor (nonsteroidal farnesoid X receptor or FXR agonist) and firsocostat (acetyl-CoA carboxylase or ACC inhibitor). Out of 20 patients who were treated...
by ltsiwpadmin | Jul 4, 2017 | Diagnostics & Therapeutic Advancements, Publications
Abstract BACKGROUND Non-alcoholic fatty liver disease is the fastest growing cause of liver disease in the Western world, yet there is no approved pharmacotherapy. While lifestyle modifications remain the mainstay of treatment, only a proportion of individuals are...
by ltsiwpadmin | May 23, 2017 | Diagnostics & Therapeutic Advancements, Publications
Abstract Ligand-activated nuclear receptors, including peroxisome proliferator-activated receptor alpha (PPARα), pregnane X receptor, and constitutive androstane receptor, were first identified as key regulators of the responses against chemical toxicants. However,...
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