by bryan | Oct 16, 2019 | Overview & Epidemiology
Cancer trends in young adults, often under 50 years, reflect recent changes in carcinogenic exposures, which could foreshadow the future overall disease burden. Previous studies reported an increase in early onset colorectal cancer, which could partly reflect the...
by bryan | Apr 15, 2019 | Overview & Epidemiology
A study of more than 4,000 young adults found more than 20 percent are walking around with dangerous levels of fat in their liver. This gives them twice the risk of suffering a cardiac event such as a heart attack, and in extreme cases can lead to liver cancer or the...
by bryan | Apr 15, 2019 | Overview & Epidemiology
Two independent national studies have reported high rates of liver disease progression and mortality among patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH). The studies reported today at The International Liver Congress™ 2019...
by ltsiwpadmin | Jul 20, 2017 | Overview & Epidemiology, Publications
Abstract The cleavage and secretion of pro-inflammatory cytokines IL-1β and IL-18 is regulated by NLRP3 (NACHT, LRR, and PYD domain-containing protein 3) inflammasome activation. Kupffer cells (KCs) are implicated in the pathogenesis of various liver diseases, such as...
by ltsiwpadmin | Jul 5, 2017 | Overview & Epidemiology, Publications
Abstract Non-alcoholic steatohepatitis (NASH) is characterized at histology by steatosis, hepatocyte ballooning and inflammatory infiltrates, with or without fibrosis. Although diamagnetic material in fibrosis and inflammation can be detected with quantitative...
by ltsiwpadmin | Jun 30, 2017 | Overview & Epidemiology, Publications
Abstract Mitochondrial dysfunction is closely associated with the pathogenesis of nonalcoholic steatohepatitis (NASH). The aim of the present study was to comprehensively determine mitochondrial abnormalities in NASH by detecting the proteomics in liver mitochondria...
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